Title: First Non-Vanishing Theorems Abstract: Dirichlet proved that there are primes in arithmetic progressions, but how big is the first? Given a prime, how large is the first quadratic non-residue? How many Fourier coefficients determine an automorphic form? In joint with Jeff Hoffstein we ask the following analogous question: for an automorphic form f on GL(r), what is the least fundamental discriminant d such that the L-function associated to f, twisted by the quadratic character chi_d, does not vanish at the center of the critical strip? Our partial answer in the cases r=1,2,3 sheds some light on the similarities and differences between using classical methods and multiple Dirichlet series.?